Seasons & Episodes
The Story of the South African Quaalude
South Africa is the last place on earth Quaaludes can still be found; Hamilton travels there to study the drug and learn
A Positive PCP Story
Hamilton investigates the history of PCP in the U.S., seeking input from addicts, dealers and chemists.
Shepherdess: The Story of Salvia Divinorium
From the heavenly cloud forests of Oaxaca to a viral video of Miley Cyrus, Hamilton investigates the inconspicuous yet e
Magic Mushrooms in Mexico
Hamilton explores magic mushrooms with the help of shamans, clandestine growers, and ethnomycologists.
Fish N' Trips
Hamilton embarks on an aquatic adventure to Reunion Island and Madagascar to investigate ichthyoallyeinotoxism and a twi
The Lazy Lizard School of Hedonism
We meet with famed LSD chemist Casey Hardison in the Nevada desert and embark on a roadtrip to visit the unsung hero of
The Psychedelic Toad
Hamilton embarks on a quest to answer the most important question in ethnoherpetological history and along the way, he f
Peyote: The Divine Messenger
From the greenhouses of Thai cactophiles to the Tamaulipan thornscrub, Hamilton traces the history of peyote with the he
Kratom: The Forbidden Leaf
Hamilton investigates the pharmacology and traditional uses of Kratom, a Thai tree with opioid-containing leaves.
Wizards of DMT
Hamilton travels across North America to study how and why DMT exists in the environment and the laboratory.
Ketamine: Realms and Realities
Hamilton heads to India to see industrial Ketamine synthesis, and speak with therapists and luminaries in an attempt to
A Clandestine Chemist's Tale
Hamilton meets an unsung hero of the psychedelic underground and hears a tragic tale of MDMA synthesis and chemiluminesc
A Fungal Fairy Tale
Hamilton ascends the Carpathian Mountains, microscope in hand, to learn how Europeans use Amanita muscaria, and uncovers
The Cactus Apprentice
Deep in the Andean highlands of Peru, Hamilton becomes the apprentice of a local shaman, learning how to use the night-b
Synthetic Toad Venom Machine
Haunted by past mistakes, Hamilton embarks on a journey to correct an error in his reporting and identifies the origin o
A Positive Methamphetamine Story
From X-ray crystallography to vesicular dopamine release, Hamilton travels the country visiting meth labs in order to un
Xenon: the Perfect Anesthetic?
Hamilton traces the multibillion year history of nitrous oxide on Earth and follows the strangest noble gas to the Czech
Synethetic Ibogaine-Natural Tramadol
After revealing a scientific mystery around Tramadol-addicted cows in Central Africa, Hamilton follows a Gabonese opiate
Bufotenine: In Search of Hataj
Succumbing to viewer requests, Hamilton journeys to South America to understand the legend of Bufotenine, the world's ol
Ultra LSD
With the precise structure of LSD's molecular target identified, Hamilton discusses the new era of psychedelic research
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